B10 Cells Alleviate Periodontal Bone Loss in Experimental Periodontitis

RANKL inhibition through osteoprotegerin blocks bone loss in experimental periodontitis.

BACKGROUND Prevention of alveolar bone destruction is a clinical challenge in periodontal disease treatment. The receptor activator of nuclear factor-kappa B ligand (RANKL) inhibitor osteoprotegerin (OPG) inhibits osteoclastogenesis and suppresses bone resorption. METHODS To study the effects of RANKL inhibition on alveolar bone loss, an experimental ligature-induced model of periodontitis wa...

The effects of local and systemic Atorvastatin on inflammation and alveolar bone loss in experimental periodontitis in rats

Objectives The frst cause of tooth loss in developed countries is periodontitis and mostly occurs in people over 40 years old.Atorvastatin is a statin drug class, which has a revolutionary impact on the treatment of high cholesterol and also stimulates bone morphogenic protein which has osteogenic potential. The aim of this study was to evaluate the effect of local and systemic Atorvastatin in...

The Effect of Alcohol Consumption on Periodontal Bone Support in Experimental Periodontitis in Rats

OBJECTIVE The aim of this study was to evaluate the effect of the alcohol consumption on the periodontal bone support (PBS) in experimental periodontitis in rats. MATERIALS AND METHODS Sixty-three male rats were divided into seven groups: G1 (control); G2 (10% ethanol); G3 (nutritional control of G2); G4 (20% ethanol); G5 (nutritional control of G4); G6 (30% ethanol) and G7 (nutritional contr...

Inflammation and bone loss in periodontal disease.

Inflammation and bone loss are hallmarks of periodontal disease (PD). The question is how the former leads to the latter. Accumulated evidence demonstrates that PD involves bacterially derived factors and antigens that stimulate a local inflammatory reaction and activation of the innate immune system. Proinflammatory molecules and cytokine networks play essential roles in this process. Interleu...

Hormone Protects against Periodontitis - associated Bone Loss